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A Practical Handbook on the Pharmacovigilance of by World Health Organization

By World Health Organization

The guide is an in depth handbook giving a step-by-step method of project the pharmacovigilance of antimalarials. it really is meant to be a resource of sensible recommendation for pharmacovigilance centres. It offers info on spontaneous reporting of inauspicious drug reactions as a supplement to different WHO guides. furthermore, it presents information on find out how to behavior cohort occasion tracking, that is a style of energetic defense surveillance accumulating details on all antagonistic occasions taking place after remedy. It additionally info how you can practice causality evaluate and sign identity, acceptable to either equipment of surveillance.

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Extra resources for A Practical Handbook on the Pharmacovigilance of Antimalarial Medicines

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Zheng & Frey, 2005). For example, if one measures the ambient concentration of an air pollutant at a specific location, there is temporal variability in the true concentration. If the measurement method has a random component to the measurement error, then the variability in the measurements over time will be larger than the true variability in the ambient concentration. Failure to deconvolute random measurement error from the observed data can lead to an overestimate of variability. Examples of random measurement errors: 1.

2006). 35 Harmonization Project Document No. , 2006). Examples of Tier 3 uncertainty analysis: 1. 2. g. ambient concentrations, indoor particulate matter emission rates from environmental tobacco smoke, indoor air exchange rates, building penetration values, particle deposition rates) are represented probabilistically with distributions statistically fitted to all available relevant data. , 2006). 3 Summary of the tiered approach The amount of effort and detail devoted to analysing uncertainties should be proportionate to the needs of the problem, and so a tiered approach is recommended.

6 2. x dust using five dust lead measurement methods, variation over methods and surface types. Technician effects, inadvertent field exposure to lead, contamination of collection equipment and laboratory instrument error were found to contribute little to total measurement error. The method chosen for studying nutrition habits may greatly influence estimations of exposure to food contaminants. g. over the last four weeks) foods consumed; (ii) the 24-h recall, where people are asked what they ate the previous day; (iii) real-time diaries, where people record what they eat (Willett, 1998); and (iv) food frequency questionnaires, where people are asked a series of questions about how often they usually consumed a particular food in, for example, the past year or past month, as well as typical portion size.

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